Kleine-Levine Syndrome Co-occuring with Bipolar Disorder.

Klein-Levine syndrome (KLS) is a rare syndrome (1-2 reported cases per 1 million) that affects mostly men in young adulthood (1,2). The etiology of KLS is unknown however the reported flu-like symptoms prior to the initial KLS attack suggest that autoimmune mechanisms and genetic factors might have a role in the ethiopathogenesis (3). The KLS attacks are characterized by hypersomnia (15-21 hour/day), cognitive impairment (apathy, confusion, slowness, amnesia), derealization (dreamy state, altered perception) and more infrequently hypersexuality and depressive mood (3). Common mechanisms as circadian rhythm abnormalities and clinical similarities indicate a possible relationship between KLS and mood disorders (1). A rare case of co-occuring KLS and bipolar disorder (BD) is presented in this report. Written consent was obtained from the patient for this presentation.